OXIDATIVE MODIFICATION OF PROTEINS IN THE SYNOVIAL FLUID OF PATIENTS WITH OSTEOARTHRITIS AFTER SARS-CoV 2-INFECTION

The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) has made a serious public health threat worldwide. It many complications and deaths, so millions people are at risk in more countries. A special group consists patients with chronic diseases, particularly osteoarthritis. is known that development osteoarthritis associated oxidative stress excessive production free radicals. Proteins highly sensitive to radical oxidation, their oxidation level reflects oxidant-antioxidant balance body. aim work was determine concentration products modification proteins sulfhydryl groups synovial fluid after SARS-CoV2 infection. All study participants were divided into two groups. first (n=22) knee joints II-III degree. second (n=14) degree, who suffered mild moderate form COVID-19 6-9 months ago. In conducted studies, protein all experimental evaluated. determined carbonyl derivatives, which detected reaction 2,4-dinitrophenylhydrazine. total, protein-bound non-protein (SH) measured Ellman method. Processing research results carried out using generally accepted methods variational statistics. established contracted COVID-19, increased. Under same conditions, decreased. changes indicate violation SARS-CoV-2 This indicates prevalence processes directly joint. Our may develop joint damage infection COVID-19.